Endocrine Abstracts

The Glucagon-like peptide-1 (GLP-1) receptor is expressed in the lung having a very important role in the modulation of the Angiotensin Converting Enzymes (ACEs). ACE1 cleaves angiotensin-I into angiotensin-II, which is converted by ACE2 to Ang(1-7). Ang(1-7) has vasodilating effects. The Idiopathic Pulmonary Fibrosis (IPF) is characterized by excessive extracellular matrix deposition disrupting the alveolar architecture and physiology. IPF develops by a sequence of inflammati...

The Glucagon-like peptide-1 receptor is widely expressed in diverse tissues including the liver. GLP-1 contributes itself to the regulation of glucose homeostasis and has important effects in lipid metabolism even preventing liver steatosis induced by high fat diets.The aim of this study was to analyse the short-term effects of liraglutide on key enzymes of the hepatic energy metabolism.Thirty-six Sprague-Dawley young adult male ra...

Adverse events during gestation in rodents, results in an enhancement of immune function, including elevated levels of inflammatory cytokines in the brain. Liraglutide is a GLP-1 receptor agonists known to exert neuroprotective effects in brain. The aim of this study was to elucidate if liraglutide given to food restricted (FR) pregnant rats may prevent the deleterious effects of FR in the hippocampal inflammatory status of male and female pups at 21 days of age (D21). 20 Spra...

Acute lung injury (ALI) is characterized by endothelial and epithelial damage, followed by inflammatory. Glucagon-like peptide-1 (GLP-1) is a gut-produced hormone with insulinotropic effects. GLP-1 receptor is expressed in the lung, and there implicated in the synthesis of surfactant proteins. We have previously shown that liraglutide (LIR), a GLP-1 receptor agonist, restores surfactant protein-B (SPB) levels, a limiting factor for survival, and also angiotensin converting enz...

Food restriction (FR) of mothers during the perinatal period, can lead to disorders in emotional behaviors at offspring. GLP-1 may play a role in the regulation of anxiety-like behavior in rodents. The aim of this study was to asses if Liraglutide (a GLP-1 receptor agonist; LIR) given to pregnant rats may prevent the deleterious effects of FR in the anxiety-like behavior in pups at 21 days and two months of age males.Twenty-five pregnant Sprague-Dawley r...

The skeletal muscle expresses the Glucagon-like Peptide 1 (GLP-1) receptor, although its effects in this tissue are not well known. Muscles are a major sink of energy substrates. The aim of our study was to examine the mid-term effect of Liraglutide (LIRA), a GLP-1 receptor agonist, in the expression of molecular indicators of the metabolic activity of the muscle, which includes enzymes, transporters, and intracellular signals. Twenty young Spague-Dawley male rats (350-400 g) ...

GLP-1 is a gut hormones with insulinotropic effects. GLP-1 is expressed at the hypothalamus having regulatory functions in food intake and neuroendocrine corticoadrenal axis (HPA). Energy balance and HPA have deep influence in the gonadal function of mammals. Exendin-4 (Ex4) is a potent agonist for the GLP-1 receptor.Objectives: To evaluate the effects of native GLP-1 (7–36)-NH2(GLP-1) and Ex4 in the function of the reproductive system in adulthood ...

Acromegaloidisms are usually reported as isolated cases that are not well characterised clinically. Indeed, most such cases were reported several decades ago, part of the reason why our knowledge about this entity is scarce. By contrast, clinical situations suggestive of acromegaly are not so infrequent, in which basal GH and IGF1 levels lie within a normal range, the GH responses to OGTT challenge are conserved and there is no radiological (MRI) evidence of hypothalamic-pitui...

Acromegaloidism includes clinical features of acromegaly with GH and IGF1 normal levels at baseline and dynamic, without findings of extrapituitary or pituitary tumour. It has been associated with various conditions without a definite pattern. The aim was to evaluate whether there are differences in some hormonal pituitary axis from acromegaloid subjects with respect to acromegalic and healthy subjects. We designed a comparative, multicenter, case–control study in three h...

Acromegaloidism is a very rare entity (have been 54 cases reported worldwide) that presents with clinical acromegaly and normal somatotropic axis, without findings of pituitary or extrapituitary tumour. Its origin has not been clearly established, although it is associated with several pathophysiological conditions. The local ethics committee approved to perform an observational and multicenter study in three hospitals from a region with approximately 800 000 people over 18 ye...